Brain organoids finally act their age
Lab-grown human neural tissue kept alive past five years transitioned into postnatal developmental stages, giving researchers a working model for late-stage brain maturation.
- Faravelli, Arlotta et al. maintained organoids for over five years — the longest reported.
- Older progenitor cells skipped early stages and produced mature neurons in about two weeks.
- Single-cell genomics and chimeric tissue mixing confirmed the postnatal timing shift.
- Opens a window on neurodegenerative disease that early-stage organoids could not.
- Cross-confirmed by phys.org write-up of the same Nature paper.