Metal ions bridge DNA strands that would otherwise repel — the pairing mystery is solved
Using a record-player-style scanning microscope combined with molecular dynamics simulations, researchers resolved how complementary DNA strands find and pair with each other — the answer being that metal ions act as transient bridges between strands that would otherwise electrostatically repel.
- DNA strands carry like-charge surfaces that should repel; the ion-bridge mechanism explains how they approach close enough to pair
- The same mechanism likely governs RNA folding and other nucleic acid processes
- Insight could inform the design of DNA-based materials and synthetic biology constructs