Bacteria Evolved a Telomerase-Mimicking Antiviral Defense
Columbia researchers characterized DRT10, a bacterial defense system that synthesizes protective cDNA using noncoding RNA templates and a reverse transcriptase whose mechanism mirrors eukaryotic telomerase. The finding closes a billion-year gap between bacterial phage immunity and a core pillar of eukaryotic chromosome maintenance.
- DRT10 uses a serine-primed reverse transcriptase to build tandem-repeat cDNA shields against phages
- The mechanism parallels telomerase, suggesting evolutionary continuity across prokaryotes and eukaryotes
- Published in Nature (DOI: 10.1038/s41586-026-11250-8); Columbia University, Sternberg lab