A plasma protein panel predicts liver disease 16 years before onset, the SenNet consortium releases a comprehensive senescence atlas, and a study finds short-term stressors may be skewing biological age clock readings.
A study of 50,000+ UK Biobank participants found that a specific set of plasma proteins could identify individuals who would develop MASLD (metabolic-associated steatotic liver disease) up to 16 years before clinical diagnosis.
Researchers found that chemotherapy triggers cancer-associated cells to become senescent, and those senescent cells then remodel the tumor environment through fructose metabolic reprogramming — a process that promotes metastasis in mouse models.
The Senescence Network (SenNet) consortium released a comprehensive multi-tissue atlas of senescent cells, cataloguing their molecular signatures across tissue types, species, and stages of the lifespan.
A study found that MEK signaling regulates T cell exhaustion partly by reducing cellular energy expenditure — suggesting exhaustion evolved as a metabolic conservation strategy rather than purely as an immune checkpoint mechanism.
A review synthesizes growing evidence that CHIP — clonal hematopoiesis of indeterminate potential, where mutant blood stem cell clones expand with age — is a significant driver of cardiovascular disease and cognitive decline independent of other risk factors.
A study examined how short-duration stressors — including meals, air pollution exposure, and acute psychological stress — affect epigenetic clock readings, finding significant transient perturbations that may confound single-point measurements.