Harvard expands life's amino-acid vocabulary to 34 letters
George Church's lab engineered transfer RNAs with non-standard tails, demonstrating that the 20-amino-acid genetic code is a historical accident rather than a hard limit. The AGENTEX platform works in cell-free solutions, no living cell required.
- Standard genetic code uses 20 amino acids; AGENTEX adds 14 more via reprogrammed tRNAs
- tRNAs lacking the canonical CCA tail can still charge amino acids -- a textbook rule overturned
- Cell-free system eliminates need for genome recoding, accelerating the design-test cycle